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盐酸Irinotecan(CPT-11)系喜树碱的半合成衍生物。根据以日本为首的多国临床试验研究,确认CPT-11对卵巢癌和子宫颈癌等具有广谱抗肿瘤作用。日本的肺癌治疗领域已经领先一步,率先进行CPT-11的研究应用;而欧美则在大肠癌二线治疗上开展CPT-11的研究受到好评。由于CPT-11的疗效得
Irinotecan hydrochloride (CPT-11) is a semisynthetic derivative of camptothecin. According to a multi-national clinical trial led by Japan, it has been confirmed that CPT-11 has a broad-spectrum anti-tumor effect on ovarian cancer and cervical cancer. Japan has taken the lead in the field of lung cancer treatment, taking the lead in CPT-11 research and application; and Europe and the United States in the second-line treatment of colorectal cancer CPT-11 research has been well received. Due to the efficacy of CPT-11