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黄嘌呤类药物应用于心绞痛的治疗,已有了近七十年的历史,这类药物的疗效如何,特别是氨茶硷对心绞痛的疗效问题,目前还存在着争论,各家论著也有矛盾。这里简单介绍一些文献材料,并讨论一些有关问题。首先阿斯康泽氏于1895年报导黄嘌呤类水杨酸钠柯柯硷,对心绞痛有一定的疗效。1925年史密斯氏等灌流(?)冠状动脉,发现:苯甲酸咖啡因和水杨酸钠柯柯硷,并不能增加冠状动脉血流量;而茶硷能增加20—45%,氨茶硷能增加40-90%。自此氨茶硷乃代替柯柯硷在这方面的应用。此后在临床上又发现动脉硬化性心脏病,这类药物不仅能减轻心绞痛,并且可增加心脏的工作效率,列维氏等(1940)给病人吸入低氧的混合气体
Xanthine drugs used in the treatment of angina, has been nearly seventy years of history, the efficacy of such drugs, especially the efficacy of aminophylline on angina pectoris, there are still controversial, there are contradictions in various books. Here is a brief introduction to some of the literature and materials, and discuss some of the issues. First, Asconze’s reported in 1895 xanthine sodium salicylate, Ke Keine, angina has a certain effect. In 1925, Smith et al perfusion (?) Coronary artery, found: benzoic acid caffeine and sodium salicylate, and did not increase coronary blood flow; and theophylline can increase 20-45%, ammonia theophylline can increase 40-90%. Since then aminophylline is to replace the use of Ke Kejing in this regard. Since then in clinical and found that atherosclerosis heart disease, these drugs can not only reduce angina and can increase the efficiency of the heart, Levi’s (1940) to the patient inhaled hypoxia mixed gas