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目的：研究烟酰胺在玻碳电极及聚吡咯电极上的电化学行为，有助于了解其在人体内的代谢情况。方法：在不同酸度的支持电解质溶液中，分别研究了烟酰胺在玻碳电极和聚吡咯修饰电极上的电化学信息，测试了不同电位范围内烟酰胺的循环伏安电化学信号和电化学反应产物的红外、紫外光谱。结果：在玻碳电极表面，烟酰胺可被分两步电化学还原为二氢吡啶和四氢吡啶结构。四氢吡啶结构的电化学还原产物有电活性，可被分步氧化为环内共轭双键结构和烟酰胺。结论：支持电解质的酸度对氧化还原峰的电流影响较大；聚吡咯（ＰＰｙ）膜对烟酰胺的还原反应有电化学催化作用。提出了烟酰胺电化学反应的机理。
Objective: To study the electrochemical behavior of nicotinamide on glassy carbon electrode and polypyrrole electrode and to understand its metabolism in human body. Methods: The electrochemical information of nicotinamide on glassy carbon electrode and polypyrrole modified electrode was studied in different acidity of supporting electrolyte. The cyclic voltammetry and electrochemical reaction of nicotinamide in different potentials were tested. Infrared and ultraviolet spectra of the product. Results: Nicotinamide can be electrochemically reduced to dihydropyridine and tetrahydropyridine structures in two steps on the surface of glassy carbon electrode. The electrochemical reduction product of the tetrahydropyridine structure is electroactive and can be oxidized in steps to an intracoconjugated double bond structure and nicotinamide. CONCLUSION: The acidity of supporting electrolyte has a great influence on the redox peak current. Polypyrrole (PPy) membrane has electrochemical catalysis on the reduction of nicotinamide. The mechanism of electrochemical reaction of nicotinamide was proposed.