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We report the first known case of both Noonan syndrome and Whipple’s disease occurring in the same patient.A 36-year-old female with history of Noonan syndrome developed fatigue,anorexia,arthritis of the knees and hands with a diffuse hyperpigmented rash,night sweats,and an unintentional fifteen pound weight loss over 4 mo.Small bowel enteroscopy demonstrated mild edematous yellowish mucosa without friability.Random small bowel biopsies revealed extensive periodic acid-Schiff positive material within the foamy macrophages.She was treated with a 12 mo course of trimethoprim-sulfamethoxazole DS with clinical improvement to baseline status.
We report the first known case of both Noonan syndrome and Whipple’s disease occurring in the same patient. A 36-year-old female with history of Noonan syndrome developed fatigue, anorexia, arthritis of the knees and hands with diffuse hyperpigmented rash, night sweats , and an unintentional fifteen pound weight loss over 4 mo. Smal bowel enteroscopy to mild edematous yellowish mucosa without friability. Random small bowel biopsies was substantially scheduled for periodic acid-Schiff positive material within the foamy macrophages. He was treated with a 12 mo course of trimethoprim -sulfamethoxazole DS with clinical improvement to baseline status.