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人类血小板有两种ＡＤＰ受体参与血小板的活化。一种受体与Ｇ蛋白中的Ｇｑ分支结合 ,另一种通过Ｇｉ与腺苷酸环化酶的抑制有关。与Ｇｉ相关的受体是抗血栓药物ｃｌｏｐｉｄｏｇｒｅｌ和ｔｉｃｌｏｐｉｄｉｎ等的作用目标。现在 ,被称为Ｐ2Ｙ12的受体终于被克隆和识别出来。研究
There are two ADP receptors involved in platelet activation in human platelets. One receptor binds to the Gq branch in the G protein and the other relates to the inhibition of adenylate cyclase via Gi. Receptors associated with Gi are targets of action of the antithrombotic drugs clopidogrel and ticlopidin. Now, the receptor called P2Y12 was finally cloned and identified. the study