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目的 为进一步研究国产降纤酶对脑梗塞的疗效。方法 采取随机双盲对照临床研究。在应用降纤酶治疗前及用药后第14天分别进行神经功能缺损评分(NDF),并进行日常生活能力评估(Barthel 氏指数)。同时检测血浆中纤维蛋白原含量、肝功和肾功。结果 降纤酶治疗组血浆纤维蛋白的原含量在用药后极显著降低(P<0.01)对肝功、肾功无影响。近期疗效降纤酶治疗组显著优于对照组。神经功能缺损评分及Barthel氏指数有显著进步(P<0.05)。结论 国产降纤酶有效地降低血浆纤维蛋白原含量是治疗急性脑梗塞有较好疗效的药物。
Objective To further study the domestic defibrase on the efficacy of cerebral infarction. Methods Randomized double-blind controlled clinical study. The neurological deficit score (NDF) was measured before treatment with defibrase and on the 14th day after administration of the defibrase and the daily living ability was evaluated (Barthel’s index). Plasma fibrinogen levels, liver function, and renal function were measured at the same time. Results The content of fibrinogen in the defibrase-treated group was significantly lower after treatment (P <0.01), but had no effect on liver function and kidney function. The recent treatment of defibrase enzyme group was significantly better than the control group. Neurological deficit scores and Barthel’s index improved significantly (P <0.05). Conclusion Domestic defibrase can effectively reduce the content of fibrinogen in the treatment of acute cerebral infarction has a good effect of the drug.