论文部分内容阅读
随访４０ 例 Ｇｒａｖｅｓ 病（ Ｇ Ｄ） 患者用１３１ Ｉ（ Ｒ Ａ Ｉ） 治疗１ 年的情况， 动态测定了治疗前后不同时期血清下丘脑垂体甲状腺相关激素浓度并对其测定结果进行了统计学处理和临床分析。结果是： Ｔ３ 、 Ｔ４ 、ｒ Ｔ３ 、 Ｆ Ｔ３ 、 Ｆ Ｔ４ 血清浓度在治疗后１ 个月最高， 治疗前次之， 治疗５ 个月后降至正常； Ｔ Ｓ Ｈ 在治疗前较低， 治疗后１ 个月基本恢复正常， 治疗５ 个月后稍高于正常； Ｔ Ｒ Ｈ 在治疗５ 个月后开始增高； Ａ Ｔ Ｇ、 Ｍ Ｃ Ａ 在治疗１ 个月时最高，治疗５ 个月后有所下降但稍高于治疗前。一过性甲减发生率为１０ ．８１ ％ ，治疗１ 年后甲减发生率为７ ．５ ％ ，治疗１ 年后好转率为９２ ．５ ％ ，甲亢危象发生率为５ ％ ；治疗前后不同时期中 Ｔ３ 、 Ｔ４ 、ｒ Ｔ３ 、 Ｆ Ｔ３ 、 Ｆ Ｔ４ 大致存在显著正相关（ Ｐ＜ ０ ．０１） ， Ｔ Ｓ Ｈ与上述５ 种激素之间存在负相关（ Ｐ＜ ０ ．０１） 。结论是： 甲亢用 Ｒ Ａ Ｉ 治疗有效、安全， 治疗前后各激素水平保持一定的相关性。
The follow-up of 40 cases of Graves disease (G D) patients with 131 I (R A I) treatment for 1 year, dynamic determination of the serum hypothalamus pituitary thyroid hormone levels at different periods before and after treatment were measured and the results were statistically analyzed and Clinical analysis. The results showed that the serum concentrations of T3, T4, r T3, F T3 and F T4 were the highest at 1 month after treatment, the last before treatment, and returned to normal after 5 months of treatment. The T S H was lower before treatment and after treatment 1 month returned to normal after 5 months of treatment slightly higher than normal; T R H began to increase after 5 months of treatment; A T G, M C A highest in the treatment of 1 month, after 5 months of treatment The decline but slightly higher than before treatment. A transient hypothyroidism rate of 10. 81%, 1 year after treatment, the incidence of hypothyroidism 7. 5%, 1 year after the treatment rate of 92 was improved. 5%, and the incidence of hyperthyroidism crisis was 5%. There was a significant positive correlation between T3, T4, r T3, F T3 and F T4 in different periods before and after treatment (P <0.01) There was a negative correlation (P <0 .01). The conclusion is: hyperthyroidism with R A I treatment is effective and safe, before and after treatment to maintain a certain degree of correlation between hormone levels.