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虽然,一些研究己证明,非胰岛素依赖型糖尿病(NIDDM)患者在病程不同阶段其血清胰岛素浓度可升高、正常或降低,但仍缺乏纵向性研究。本文对糖耐量减退(IGT)期间,IGT 和 NIDDM 发生后患者的血清胰岛素浓度变化进行了前瞻性研究。病人和方法 132例未经药物治疗的患者,根据病情及检查结果编入以下4组:第1组81例,为初次检查时糖耐量正常,平均2.8年后出现 IGT 者;第2组44例,为检查时有 IGT,平均3.1年后诊断为NIDDM 者;第3组27例,是已诊断为 NIDDM,经平均2.9年随访者;第4组11例,开始口服葡萄糖耐
Although some studies have demonstrated that patients with non-insulin dependent diabetes mellitus (NIDDM) have elevated, normal or decreased serum insulin levels at different stages of the disease, there is a lack of longitudinal studies. This article prospectively studied the changes of serum insulin in patients with impaired glucose tolerance (IGT) after IGT and NIDDM. Patients and Methods A total of 132 patients without medical therapy were enrolled in the following four groups according to their condition and test results: Group 1: 81 patients with normal glucose tolerance at initial examination and an average of 2.8 years after IGT; Group 2: 44 patients , IGT for examination, an average of 3.1 years after the diagnosis of NIDDM; Group 3 27 cases have been diagnosed with NIDDM, an average of 2.9 years of follow-up; the fourth group of 11 patients, began oral glucose tolerance