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用定期定量腹腔注射右旋糖酐铁观察高剂量铁对大鼠主要脏器的病理损伤。结果显示高剂量铁可使大鼠心、肝、脾、肺铁的蓄积量明显增加 （ Ｐ ＜ ００１） ，镜下观察这些脏器均出现不同程度的病理损伤。
Routine quantitative intraperitoneal injection of iron dextran was used to observe the pathological changes of the main organs of rats. The results showed that high dose of iron could significantly increase the accumulation of iron, heart, liver, spleen and lung in rats (P <001). There were some pathological lesions in these organs observed by microscope.