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平均动脉血压是由心脏搏出量和周围血管总阻力所决定的。常用的降压药是通过减少心脏搏出量来降压的,此时周围血管总阻力,特别是重要器官如脑、冠脉和肾脏等血管阻力并无重要改变。而局部血流量要取决于平均动脉血压/局部血管阻力的比率,如将动脉血压降低而局部血管阻力不变,局部血流量就必然会减少。肾血流量减少使肾小球滤过率下降;如果肾功能本已明显降低,则使用降压药物就会引
The mean arterial blood pressure is determined by the amount of cardiac stroke and the total resistance around the blood vessels. Commonly used antihypertensive drugs by reducing stroke volume stroke to reduce blood pressure, when the total vascular resistance around, especially important organs such as brain, coronary and kidney vascular resistance and no significant changes. The local blood flow depends on the average arterial blood pressure / local vascular resistance ratio, such as arterial blood pressure decreased while local vascular resistance unchanged, the local blood flow will inevitably be reduced. Reduced renal blood flow decreased glomerular filtration rate; if the renal function has been significantly reduced, the use of antihypertensive drugs will lead