论文部分内容阅读
目的探讨宫腔镜下子宫内膜息肉电切术后应用左炔诺孕酮宫内缓释系统(LNG-IUS)预防子宫内膜息肉复发的疗效。方法将2009年8月-2011年8月郑州大学第一附属医院因子宫内膜息肉行宫腔镜下子宫内膜息肉电切术的60例患者,采用完全随机化分组法分为研究组(30例,术后放置LNG-IUS)和对照组(30例,术后未行特殊处理)。随访比较两组患者术后6、12、24个月子宫内膜息肉复发、血红蛋白水平和子宫内膜厚度。结果研究组患者治疗后24个月血红蛋白水平[(120.15±9.51)]g/L显著增加(P<0.05);术后6、12、24个月子宫内膜厚度[(0.57±0.14)mm、(0.79±0.21)mm、(0.93±0.22)mm]均低于治疗前[(1.46±0.56)mm](P<0.05);术后24个月子宫内膜息肉的复发率(6.90%,2/29)与对照组(39.29%,11/28)比较,差异有统计学意义(P<0.05)。所有患者术后均无严重并发症发生,术后24个月随访,研究组2例(6.90%,2/29)患者有阴道淋漓出血。结论左炔诺孕酮宫内缓释系统能有效预防子宫内膜息肉复发,值得在临床推广。
Objective To investigate the efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the prevention of recurrence of endometrial polyps after hysteroscopic endometrial polypectomy. Methods Sixty patients with endometrial polyps underwent hysteroscopic endometrial polyp resection from August 2009 to August 2011 in the First Affiliated Hospital of Zhengzhou University were randomly divided into study group (30 Cases, postoperative LNG-IUS) and control group (30 cases, no special treatment after surgery). The recurrence of endometrial polyps, hemoglobin and endometrial thickness at 6, 12 and 24 months after operation were compared between the two groups. Results The hemoglobin level in the study group was significantly increased at 24 months ([120.15 ± 9.51] g / L, P <0.05), and the thickness of endometrium at 6, 12 and 24 months after the operation was [(0.57 ± 0.14) (0.79 ± 0.21) mm, (0.93 ± 0.22) mm] were lower than those before treatment [(1.46 ± 0.56) mm] (P <0.05). The recurrence rate of endometrial polyps at 24 months / 29) compared with the control group (39.29%, 11/28), the difference was statistically significant (P <0.05). No postoperative complications were found in all patients. After 24 months of follow-up, 2 patients (6.90%, 2/29) in the study group had vaginal bleeding. Conclusion Levonorgestrel intrauterine system can effectively prevent the recurrence of endometrial polyps, it is worth in the clinical promotion.