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目的:研究胰腺癌血小板参数及功能的变化并探讨其临床意义。方法:以PLT、MPV、PDW、PCT四项指标反映血小板参数,以PAF、TXB_2、PAgT、PAdT等指标反映血小板功能,并与正常人群对照。结果:与正常人相比,胰腺癌病人PLT、PCT明显下降(P<0.01),MPV、PDW升高(P<0.01),PAF、TXB_2、PAgT、PAdT均明显升高(P<0.01)。结论:在晚期胰腺癌病人,血小板参数有明显变化,血小板功能明显增强,这种变化是肿瘤自身变化的必然结果,并与肿瘤的生长、浸润及转移有关。
Objective: To study the changes of platelet parameters and functions in pancreatic cancer and to explore its clinical significance. Methods: Four parameters of PLT, MPV, PDW and PCT were used to reflect the platelet parameters, PAF, TXB_2, PAgT and PAdT were used to reflect the platelet function and were compared with normal controls. Results: Compared with normal controls, the levels of PLT and PCT in pancreatic cancer were significantly decreased (P <0.01), MPV and PDW were increased (P <0.01), PAF, TXB_2, PAgT and PAdT were significantly increased (P <0.01). CONCLUSIONS: In patients with advanced pancreatic cancer, there are significant changes in platelet parameters and platelet function. This change is an inevitable consequence of tumor self-change and is related to tumor growth, invasion and metastasis.