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目的探讨消旋卡多曲联合利巴韦林治疗小儿轮状病毒肠炎的治疗效果。方法回顾性分析2015年1月—2016年1月徐州市妇幼保健院87例门诊小儿轮状病毒肠炎患儿的临床资料,按治疗方案不同分为对照组37例与研究组50例。对照组患儿给予利巴韦林治疗,研究组患儿在对照组础上给予消旋卡多曲治疗,比较两组患儿退热时间、止泻时间、止吐时间及治疗时间,治疗后检测两组轮状病毒转阴情况;并记录两组患儿不良反应发生情况。结果研究组患儿退热时间、止泻时间、止吐时间及治疗时间均短于对照组,体内轮状病毒转阴率高于对照组,差异有统计学意义(P<0.05);两组患儿治疗期间均未出现明显不良反应事件。结论消旋卡多曲联合利巴韦林治疗小儿轮状病毒肠炎的疗效明显,可提高轮状病毒转阴率,改善患儿病情,加速其康复进程,且不良反应少。
Objective To investigate the therapeutic effect of racecadotril combined with ribavirin on rotavirus enteritis in children. Methods The clinical data of 87 outpatients with pediatric rotavirus enteritis in Xuzhou MCH hospital from January 2015 to January 2016 were retrospectively analyzed. According to the different treatment plans, 37 cases were divided into control group and 50 cases in study group. Control group children given ribavirin treatment, the study group children in the control group given racecadotril treatment, the two groups of children with antipyretic time, antidiarrheal time, antiemetic time and treatment time, after treatment Detection of two rotavirus negative cases; and recorded two groups of children with adverse reactions. Results The antipyretic time, antidiarrheal time, antiemetic time and treatment time in the study group were shorter than those in the control group. The rotavirus negative rate in the study group was higher than that in the control group (P <0.05) No significant adverse events occurred during the treatment of children. Conclusion The anticoccidial combined with ribavirin treatment of pediatric rotavirus enteritis has obvious curative effect, which can increase the rotavirus negative rate, improve the condition of children and speed up the rehabilitation process, and the adverse reactions are few.