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目的 研究溶剂汽油对皮肤屏障功能的影响。方法 大鼠活体染毒后 ,分离皮肤 ,采用皮肤静式渗透装置 ,测定氚水 (3 H)经皮渗透量。结果 连续接触溶剂汽油 0 .5、1、2h组的大鼠皮肤 ,氚水经皮渗透量有所增加 ,但与对照组相比无统计学差异。而接触溶剂汽油 4h组 ,氚水经皮渗透量在各采样时段 ,均明显高于对照组(P <0 .0 5 )。在同一采样时段 ,有随接触时间延长氚水渗透量逐渐增加的趋势 ;各组氚水经皮渗透量均随时间的延长而增加。结论 接触溶剂汽油达到一定时间 ,可造成皮肤屏障功能的损伤。
Objective To study the effect of solvent gasoline on skin barrier function. Methods After the rats were exposed to the virus in vivo, the skin was separated and the transdermal permeation of tritiated water (3 H) was measured by the skin static osmotic device. Results The percutaneous penetration of tritiated water in rat skin exposed to solvent gasoline for 0.5, 1 and 2h groups was increased, but no significant difference compared with control group. However, the permeation amount of tritiated water in each group was significantly higher than that of the control group (P <0. 05). During the same sampling period, there was a trend that the permeation amount of tritiated water increased gradually with the prolongation of contact time. The transdermal permeation amount of tritiated water in each group increased with time. Conclusion Exposure to solvent gasoline for a certain period of time can cause skin barrier function damage.