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目的探讨吸烟对原发性肝癌患者凝血功能的影响。方法 97例确诊为原发性肝癌的初诊患者,根据吸烟指数不同分为1组(吸烟指数为0,26例),2组(吸烟指数为1~199,21例),3组(吸烟指数为200~399,22例),4组(吸烟指数为>400,28例)。对比四组的C反应蛋白(CRP)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)、血小板计数(PLT)。结果 1组和2组、3组和4组患者之间的PLT、PT、APTT、D-D、FIB、CRP检验指标比较,差异均无统计学意义(P>0.05)。1、2合并组PT、APTT高于3、4合并组,PLT、D-D、FIB、CRP低于3、4合并组,差异均具有统计学意义(t=9.930、2.578、548.266、3.977、4.594、118.708,P<0.05)。结论长期吸烟可介导肝癌患者长期处于慢性炎症反应状态,并影响原发性肝癌患者的凝血功能。
Objective To investigate the effect of smoking on the coagulation function in patients with primary liver cancer. Methods A total of 97 newly diagnosed patients with primary hepatocellular carcinoma (HCC) were enrolled in this study. One group was divided into two groups based on the smoking index (smoking index was 0 and 26), two groups (smoking index was 1 to 199, 21 cases), three groups (smoking index 200 ~ 399,22 cases), 4 groups (smoking index> 400,28 cases). The levels of C-reactive protein (CRP), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (DD), platelet count (PLT) . Results The indexes of PLT, PT, APTT, D-D, FIB and CRP between group 1 and group 2, group 3 and group 4 were not significantly different (P> 0.05). 1, 2, PTT and APTT in the combined group were higher than those in the combined group of 3 and 4, and the differences were statistically significant (P = 0.912, 118.708, P <0.05). Conclusion Long-term smoking can mediate long-term chronic inflammation in patients with hepatocellular carcinoma and affect the coagulation function in patients with primary liver cancer.