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门脉高压(portal hypertension, PHT)患者可产生不同程度的胃粘膜病变(gastric mucosal lesion, GML),Smark等将其称为门脉高压性胃病(portal hyperten-sive gastropathy, PHG),其发生率在50％以上,它引起的上消化道出血(upper gastrointestinal bleeding, UGIB)达10％～60％。病变包括炎症、糜烂、溃疡、出血等。近年国内外越来越多的学者致力于其发病机制的研究,并取得了突破性进展,一致认为PHG的发病是多因素的,共同使胃粘膜攻击因子与防御因子平衡失调所致。本文将近年国内外在这一方面的研究情况作一综述。
Patients with portal hypertension (PHT) develop varying degrees of gastric mucosal lesion (GML), and Smark et al. Call this a portal hyperten- sive gastropathy (PHG), the incidence of which Above 50% it causes up to 10% to 60% upper gastrointestinal bleeding (UGIB). Lesions include inflammation, erosion, ulcers, bleeding and the like. In recent years, more and more scholars at home and abroad are devoted to the study of their pathogenesis and have made breakthrough progress. They all agree that the incidence of PHG is multifactorial, which brings about the imbalance of gastric mucosal attack factor and defensive factor. This article summarizes the research situation in this area at home and abroad in recent years.