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目的 :探讨大肠癌根治术门静脉插管 5 -Fu化疗预防肝转移的疗效。方法 :87例DukesB、C期大肠癌患者 ,随机双盲分组 :根治性切除加门静脉化疗 45例 (治疗组 )及单纯根治性切除 42例 (对照组 )。治疗组于根治术当日即以 5 -Fu 1g持续 2 4小时门静脉滴注化疗 7天 ;对照组住院期间不作辅助化疗。结果 :治疗组肝转移发生率明显低于对照组 ,DukesC期术后 3 ,5年生存率也显著高于对照组 ,DukesB ,期无明显差异。结论 :大肠癌根治术门静脉插管预防性化疗 ,可有效降低肝转移的发生率 ,提高DukesC期患者 3、5年生存率。
Objective: To investigate the curative effect of portal vein catheterization of 5-Fu on the prevention of liver metastasis in radical operation of colorectal cancer. Methods: A total of 87 patients with DukesB and C colorectal cancer were randomly divided into two groups: radical resection plus portal vein chemotherapy in 45 patients (treatment group) and radical resection in 42 patients (control group). The treatment group on the day of radical surgery that 5-Fu 1g sustained 24 hours of portal vein infusion chemotherapy for 7 days; control group hospitalized without adjuvant chemotherapy. Results: The incidence of hepatic metastasis in the treatment group was significantly lower than that in the control group. The survival rates at 3 and 5 years after DukesC were also significantly higher than those in the control group, DukesB and no significant difference. Conclusion: Preoperative chemoembolization with portal vein catheterization for colorectal cancer can effectively reduce the incidence of liver metastases and improve the 3- and 5-year survival rates of DukesC patients.