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目的 探讨胰腺癌组织中血管内皮生长因子 (VEGF)及p5 3蛋白的表达及其临床病理意义。方法 采用SP免疫组织化学方法 ,对 46例胰腺癌组织中VEGF及 p5 3蛋白的表达进行检测。结果 VEGF与 p5 3表达率分别为 65 .2 %和 5 8.7%。p5 3表达与VEGF表达呈明显正相关(P <0 .0 5 )。VEGF表达与胰腺癌淋巴结转移 (P <0 .0 5 )和远处转移 (P <0 .0 1)显著相关 ,而与肿瘤大小 ,病理学分级无关 ,p5 3表达与胰腺癌远处转移 (P <0 .0 5 )显著相关 ,而与肿瘤大小 ,病理学分级及淋巴结转移无关。结论 在胰腺癌中 ,VEGF表达与 p5 3蛋白的表达呈正相关 ,在胰腺癌的转移中起重要作用
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and p5 3 protein in pancreatic cancer and its clinicopathological significance. Methods SP immunohistochemistry was used to detect the expression of VEGF and p53 protein in 46 cases of pancreatic cancer. Results The expression rates of VEGF and p5 3 were 65.2% and 57.7% respectively. The expression of p5 3 was positively correlated with the expression of VEGF (P <0.05). VEGF expression was significantly associated with lymph node metastasis (P <0.05) and distant metastasis (P <0.01) in patients with pancreatic cancer, but not with tumor size and pathological grade, and the expression of VEGF was associated with distant metastasis of pancreatic cancer P <0.05), but not with tumor size, pathological grade and lymph node metastasis. Conclusion In pancreatic cancer, the expression of VEGF is positively correlated with the expression of p5 3 protein and plays an important role in the metastasis of pancreatic cancer