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粒子治疗是癌症治疗的有效手段之一,受到越来越多的关注。简述了质子治疗中的治疗系统和点扫描照射技术。利用开发的扫描照射的仿真程序,参照中国科学院上海应用物理研究所正在研制的国产首台质子治疗装置的技术指标,模拟点扫描对固定靶区和运动靶区的照射,以及加速器关断延迟对剂量分布的影响,得到在给定体积靶区照射时的总照射时间和剂量率等信息。固定靶区照射时,得到适形的剂量分布;考虑加速器关断延迟时,剂量分布与计划剂量差异较大。门控技术显著改善受呼吸运动影响的靶区的照射效果。模拟结果为正在研制的装置和将来的临床应用提供必要的参考。
Particle therapy is one of the effective means of cancer treatment, which receives more and more attention. Briefly describe the proton therapy treatment system and point-scan irradiation technique. With the development of the scanning irradiation simulation program, reference to the Chinese Academy of Sciences, Shanghai Institute of Applied Physics is developing the first domestic proton therapy device technical indicators, simulate the point of the fixed target and the target area of the target irradiation, and the accelerator off delay on Dose distribution of the impact of a given volume of target irradiation time and the total exposure time dose rate and other information. When the target is fixed, a conformal dose distribution is obtained. When the delay of the accelerator is turned off, the dose distribution differs greatly from the planned dose. The gating technique significantly improves the exposure of target areas affected by respiratory movements. The simulation results provide the necessary reference for the device under development and future clinical application.