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系统性红斑狼疮(systemic lupus erythematosus．SLE)是一种以机体内广泛的免疫异常和多器官功能损伤为特征的自身免疫性疾病,其临床表现多种多样,病情往往呈缓解和恶化交替进行。自身抗体形成和免疫复合物沉积所致的组织损伤是该病的特点之一。其中,大多数的自身抗体是针对DNA和核小体的,这是SLE的一大免疫学特征,由此提出一种假说：抗原递呈细胞(APC)对凋亡细胞不恰当的处理导致了
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a wide range of immune abnormalities and multiple organ dysfunction in the body. The clinical manifestations are diverse and the disease often alternates between remission and worsening. Tissue damage caused by autoantibody formation and immune complex deposition is one of the hallmarks of the disease. Among them, the majority of autoantibodies are directed against DNA and nucleosomes, which is a large immunological feature of SLE, thereby proposing a hypothesis that improper treatment of apoptotic cells by antigen-presenting cells (APCs) leads to