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目的探讨动脉化疗泵置入治疗晚期胰头癌的疗效。方法本组24例经B超、CT诊断为胰头癌且临床有黄疸症状的病人,18例行胆总管空肠Roux-cn-Y吻合;6例行胆囊空肠Roux-en-Y吻合解除胆道梗阻。经胃网膜右动脉进行插管安放化疗泵。病人情况良好时,采用联合化疗药物灌注。术中注入5-FU1000mg、阿霉素60mg、丝裂霉素8mg。术后视病情再按期行药物灌注。结果术后病人黄疸消失,疼痛缓解,生存时间6～12个月9例,13～24个月14例,有1例生存时间长达29个月。2例病人经CT检查与术前对照肿瘤缩小。结论对手术不能切除的晚期胰头癌行动脉化疗泵置入,联合化疗,有较好的疗效。
Objective To investigate the effect of arterial chemotherapy pump in the treatment of advanced pancreatic head cancer. Methods Twenty-eight patients underwent choledochojejunostomy and Roux-en-Y anastomosis in 24 patients diagnosed as pancreatic head cancer and clinical jaundice by CT scan. Six patients underwent choledochojejunostomy with Roux-en-Y anastomosis to relieve biliary obstruction . The right gastric artery catheter intubation chemotherapy pump. When the patient is in good condition, the combination chemotherapeutic drug infusion is used. Intraoperative injection of 5-FU1000mg, doxorubicin 60mg, mitomycin 8mg. Depending on the condition after surgery as scheduled drug perfusion. Results Postoperative patients with jaundice disappeared, pain relief, survival time of 6 to 12 months in 9 cases, 13 to 24 months in 14 cases, 1 case of survival up to 29 months. Two cases of patients by CT examination and control of tumor shrinkage. Conclusion The treatment of advanced pancreatic cancer with intra-arterial chemotherapy pump which can not be excised surgically has better curative effect.