糖尿病小鼠尿素循环的变化及其机理的初步探讨

• 作 者: 周群 毛良 陈卫星 宋菊敏
• 机 构: 上海中医学院生化研究组,上海中医学院生化研究组,上海中医学院生化研究组,上海中医学院生化研究组,
• 出 处: 天津医药
• 发表日期: 1987年06期
• 关键词: 糖尿病小鼠 尿素循环 肝线粒体 环核苷酸 尿尿素氮 氧耗 同位素室 断头处死 精氨酸酶 胰高血糖素

本文观察了四氧嘧啶糖尿病小鼠尿素循环的异常变化,并初步探讨了引起这些变化的机制。结果表明,糖尿病小鼠血和尿尿素氮含量和肝精氨酸酶活力明显增高,肝氧耗速率却无显著性变化。病鼠血浆 cAMP 含量明显增高,而血浆和肝脏 cGMP 含量明显降低。这些结果提示,糖尿病动物尿素循环的异常增高,可能与其体内环核苷酸含量的变化有关,而不是直接通过肝线粒体能量代谢降低引起的。

This article observed the abnormal changes of urea cycle in alloxan diabetic mice, and initially explored the mechanism of these changes. The results showed that blood and urine urea nitrogen and liver arginase activity were significantly increased in diabetic mice, but there was no significant change in hepatic oxygen consumption rate. The plasma level of cAMP was significantly increased in the diseased mice, while the cGMP levels in plasma and liver were significantly decreased. These results suggest that the abnormal increase of urinary circulation in diabetic animals may be related to changes in the content of cyclic nucleotides in vivo rather than directly reducing the energy metabolism of mitochondria through the liver.