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目的研究连续8天摄入低剂量或高剂量酒精、普通白酒和低氘白酒对人体脑电图上的alpha波相对功率值、alpha衰减系数(AAC)、主观感觉和血液中5-羟色胺含量的影响,探讨低氘白酒对人体中枢神经功能的影响并分析其可能的机制。方法 11名平均年龄为23.7±1.3岁的健康成年男性参加本实验。实验期间受试者分别饮用低剂量酒精、高剂量酒精、低剂量白酒、高剂量白酒、低剂量低氘白酒和高剂量低氘白酒。30min后检测脑电图,并计算α衰减系数(alpha attenuation coefficient,AAC)和alpha相对功率值,用视觉模拟评分法(visual analogue scale,VAS)测试受试者的舒适感和工作效率,作为主观评价的指标,同时采血样用于5-羟色胺含量的分析。结果α衰减系数结果显示,饮用高剂量酒精后AAC升高,其他组未见明显改变。与对照组相比,α波的平均功率值在饮用高、低剂量的酒精和白酒后均有明显下降,而饮用低氘白酒后α波的平均功率值未见明显下降,且比酒精和白酒组高,表明饮用酒精和白酒能使α波活动减少,而低氘白酒无此不良反应。血浆5-羟色胺的分析结果表明,饮用低剂量低氘白酒时血浆内的5-羟色胺水平最高,说明低氘白酒能引起人大脑的舒适感升高。结论饮用酒精和普通白酒能使人体脑电图上的α平均功率值下降,人体的舒适感和工作效率降低,而低氘白酒能使人体的α波相对功率值、舒适感、工作效率和5-羟色胺的含量都维持在较高的水平上,即饮用低氘白酒时,人体中枢神经的功能可维持在较为平衡稳定的水平上,避免调控的失衡的发生。
Objective To study the effects of low or high dose alcohol, normal white spirit and deuterium-depleted white spirit on the EEG relative power, alpha attenuation coefficient (AAC), subjective feeling and serotonin Influence, explore the deuterium white wine on human central nervous system function and analyze its possible mechanism. Methods Eleven healthy adult men with mean age of 23.7 ± 1.3 years participated in the experiment. During the experiment, subjects were drinking low-dose alcohol, high-dose alcohol, low-dose liquor, high-dose liquor, low-deuterium low-dose liquor and high-dose low-deuterium liquor. The electroencephalogram (EEG) was measured after 30 minutes, and the alpha attenuation coefficient (AAC) and alpha relative power were calculated. The visual analogue scale (VAS) was used to test the comfort and work efficiency of the subjects as subjective Evaluation of the indicators, while taking blood for serotonin content analysis. Results α attenuation coefficient results showed that drinking high-dose alcohol AAC increased, no significant change in the other groups. Compared with the control group, the average α-wave power value in drinking high and low doses of alcohol and liquor decreased significantly after drinking deuterium-depleted liquor α wave average power value no significant decline, and alcohol and liquor High group, indicating that drinking alcohol and liquor can reduce α-wave activity, and low deuterium liquor without such adverse reactions. Analysis of plasma serotonin results showed that drinking low-deuterium-depleted liquor plasma serotonin levels highest, indicating that deuterium-depleted liquor can cause increased human brain comfort. Conclusions Drinking alcohol and common white spirit can decrease the α-average power of the human EEG, and reduce the comfort and work efficiency of the human body. However, the deuterium-depleted white wine can make the body relative α-wave power, comfort, work efficiency and 5 - Serotonin levels are maintained at a high level, that drinking low deuterium liquor, the body’s central nervous function can be maintained at a more balanced and stable level, to prevent the occurrence of imbalance in regulation.