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硝苯吡啶(临床也称心痛定)在治疗心血管疾病的作用已为所众知,近年来用心痛定治疗消化、呼吸、神经、泌尿及生殖系统疾病取得的显著疗效也越来越引起重视。结合我院临床应用效果总结如下:1 呼吸系统疾病1.1 对支气管哮喘的治疗:支气管哮喘是支气管平滑肌痉挛所致。是由于钙离子通过慢通道的细胞外向细胞内流动和由细胞器向胞浆的基质转移,促进了支气管平滑肌肥大细胞释放化学物质,嗜酸性粒细胞的化学趋向性和胆碱能神经兴奋波的传导。而心痛定能阻断钙离子慢通道,阻止钙离子内流,使胞浆钙离子深度降低,从而防止免疫性或非抗原性刺激引起的支气管平滑肌收缩,阻抑肥大细胞、嗜酸性粒细胞等释放组织胺、SRS—A和血小板激活因子,抑制被动致敏支气管和人肺片段释放IgE介导的SRS—A。苏惠茹报告50
Nifedipine (also known as the clinical determination of nifedipine) in the treatment of cardiovascular disease has become known, in recent years with the heart pain for the treatment of digestive, respiratory, neurological, urological and reproductive system diseases have also drawn the remarkable effect of more and more attention . Combined with the clinical application of our hospital are summarized as follows: 1 respiratory diseases 1.1 on the treatment of bronchial asthma: Bronchial asthma is caused by bronchial smooth muscle spasm. Is due to the migration of calcium ions through the extracellular channel of the slow pathway and the transfer of organelles to the cytosolic matrix, promoting bronchial smooth muscle mast cell release chemicals, eosinophilic chemotaxis and conduction of cholinergic nerve excitement waves . And heartache will be able to block the slow channel of calcium ions to prevent the influx of calcium ions, so that the depth of cytoplasmic calcium ions to reduce, so as to prevent immune or non-antigenic stimulation of bronchial smooth muscle contraction, suppression of mast cells, eosinophils, etc. The release of histamine, SRS-A and platelet activating factor inhibits IgE-mediated SRS-A release from passively sensitized bronchi and human lung segments. Su Hui Ru report 50