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成纤维细胞生长因子受体3(FGFR3)是跨膜的酪氨酸蛋白激酶受体家族成员之一,近年大量的研究表明,FGFR3基因的突变与病理分级、临床分期低的尿路上皮癌有密切的相关性,有可能成为对尿路上皮癌诊断、进行监测随访的分子标志物和治疗的靶点。本文就FGFR3基因在尿路上皮癌中作用的研究进展作一综述。
FGFR3 is a member of the transmembrane tyrosine kinase receptor family. In recent years, a large number of studies have shown that mutations in FGFR3 gene are associated with pathological grade, low clinical stage urothelial carcinoma The close correlation may become a potential target for the diagnosis and follow-up of molecular markers and treatment of urothelial carcinoma. This article reviews the research progress of FGFR3 gene in urothelial carcinoma.