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采用10μg/次乙肝疫苗以0、1、6月程序经肌肉接种被认为是目前最佳的乙肝免疫方案。按此方法,80～95%被接种者可产生足够的抗-HBs 抗体。但由于乙肝疫苗价格较高,在许多经济较落后地区普遍使用仍有一定困难,一些学者尝试以小剂量乙肝疫苗经皮内接种预防乙肝,获得了较满意效果,但未见有大面积接种的观察报告。为提高农村地区乙肝疫苗的接种率,探索在乙肝高发地区有效地阻止乙型肝炎在儿童中水平传播的方法,我们于1990年对南宁市江西乡约5000名6～14岁儿童给予小剂量乙肝疫苗经皮内接种,并抽样作血清学效果观察,现将结果报告如下:
Using 10 μg / dose of hepatitis B vaccine for 0, 1, and 6 months of course of muscle vaccination is considered the best hepatitis B immunization program. According to this method, 80 to 95% of vaccinated persons can produce enough anti-HBs antibodies. However, due to the high price of hepatitis B vaccine, it is still difficult to be widely used in many economically less developed regions. Some scholars tried to prevent hepatitis B by transdermal inoculation with a small dose of hepatitis B vaccine, but satisfactory results were obtained. However, no large area vaccination Observation report. In order to improve the coverage of hepatitis B vaccination in rural areas and explore ways to effectively prevent the horizontal transmission of hepatitis B in children in areas with high incidence of hepatitis B, we administered a small dose of hepatitis B to about 5,000 children aged 6-14 in Jiangxi’s Jiangxi Province in 1990 Vaccines were inoculated intradermally and sampled for serological observation, the results are reported as follows: