论文部分内容阅读
本文叙述吗啡和度冷丁等镇痛药与氮芥类药物在体内的交互作用。给体重20～30g成年雌、雄小白鼠分别皮下注射硫酸吗啡(5、10及25mg/kg)或盐酸度冷丁(5,25或50mg/kg)30分钟后,给亚致死量的环磷酰胺(300mg/kg)或氮芥(5mg/kg),观察7天致死率。结果表明,氮芥5mg/kg,无动物死亡;先给硫酸吗啡(5、10或25mg/kg)再给氮芥则致死率分别为50、60和100%。氮芥为10mg/kg时,二天内动物死亡20%;先给硫酸吗啡(5、10及25mg/kg)再给氮芥,则致死率分别增加到80、90及100%;若先给度冷丁再给氮芥(10mg/kg),
This article describes the interaction of analgesics such as morphine and meperidine with nitrogen mustards in vivo. To adult female and male mice weighing 20-30 g, subcutaneous lethal doses of cyclophosphamide (5, 25 mg / kg) and morphine (5, 10 and 25 mg / kg) (300mg / kg) or nitrogen mustard (5mg / kg), the mortality was observed for 7 days. The results showed that the nitrogen mustard 5mg / kg, no animal death; giving morphine sulfate (5,10 or 25mg / kg) to give nitrogen mustard fatality rates were 50,60 and 100%. Nitrogen mustard 10mg / kg, animal deaths within 20 days 20%; given sulfate morphine (5,10 and 25mg / kg) to nitrogen mustard, the mortality increased to 80,90 and 100% Campylobacter again give nitrogen mustard (10mg / kg),