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自1962年,Gross和Lapiere从蝌蚪的皮肤中首次发现基质金属蛋白酶（MMPs）的第一个成员一胶原酶以来,一系列的MMP家族成员已被陆续发现,迄今为止至少有19种MMP被发现。MMPs是一类锌离子依赖的蛋白水解酶,参与细胞外基质的降解。它们在有机体生长发育中的细胞外基质（ECM）更新与重塑以及疾病中的病理损害起着极为重要的作用。所有基质金属蛋白酶都受到天然抑制剂金属蛋白酶组织抑制剂（TIMPS）所抑制。两者的调节平衡在创伤修复、组织重建、新生血管和瘢痕形成
Since Gross and Lapiere first discovered collagenase in the skin of tadpoles in 1962 as the first member of the matrix metalloproteinases (MMPs), a series of members of the MMP family have been successively discovered. At least 19 MMPs have so far been found . MMPs are a class of zinc-dependent proteolytic enzymes involved in the degradation of extracellular matrix. They play an extremely important role in the renewal and remodeling of the extracellular matrix (ECM) in the growth and development of organisms as well as the pathological damage in diseases. All matrix metalloproteinases are inhibited by the natural inhibitor of metalloproteinase tissue inhibitor (TIMPS). The balance between the two in wound repair, tissue reconstruction, angiogenesis and scarring