论文部分内容阅读
目的:利用功能磁共振成像及认知功能测试研究青少年双相障碍(PBD)缓解相脑功能及认知功能改变状况。方法:采集PBD缓解相患者及正常青少年的功能磁共振成像信号(各16例),计算信号低频振幅,对被试进行认知功能测试,并分析两者的相关性。结果:与对照组相比,PBD缓解相组的低频振幅数值在右侧小脑、右侧颞上回及左侧海马旁回显著增加,在左侧枕中回、左侧楔叶及右侧枕上回显著降低(P<0.01,FDR校正)。右侧小脑与Stroop1测试结果负相关,左侧枕中回与数字广度-倒背测试结果正相关。结论:PBD缓解相会出现颞叶、小脑、边缘系统及枕叶自发神经活动紊乱,且小脑和枕中回的异常与PBD缓解相认知功能损伤有关。
OBJECTIVE: To study the use of functional magnetic resonance imaging (MRI) and cognitive function tests (PBD) to study the phase of brain function and cognitive function in children with bipolar disorder (PBD). Methods: PBGs were collected from 16 patients in each phase and normal controls. The amplitude of signal was calculated and the cognitive function of the subjects was tested. The correlation between them was analyzed. Results: Compared with the control group, the amplitude of low amplitude of PBD remission phase group increased significantly in the right cerebellum, the right superior temporal gyrus and the left parahippocampal gyrus. In the left and right occipital gyrus, Returned significantly lower (P <0.01, FDR correction). The right cerebellum was negatively correlated with the Stroop1 test result, and the left midcourt was positively correlated with the digital breadth-back test result. Conclusion: The spontaneous neural activity of the temporal lobe, cerebellum, limbic system and occipital lobe is disturbed in PBD remission, and the abnormalities in the cerebellum and middle occipital lobe are related to cognitive impairment of PBD remission phase.