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目的寻找导致脑膜瘤瘤周水肿的相关因素 ,探讨瘤周水肿产生的机制。 方法依据影像学资料对18例患者的瘤周水肿程度作半定量评分 ,用Logistic回归分析肿瘤大小、病理类型、肿瘤包膜是否完整、有无引流静脉受压 ,肿瘤组织的恶性程度 ,血管内皮生长因子 (vascu1arendothelialgrowthfactor,VEGF)免疫组织化学染色与瘤周水肿的相关性。 结果脑膜瘤瘤周水肿与肿瘤大小、有无引流静脉受压、病理类型、肿瘤组织的恶性程度无相关性 ,与肿瘤包膜是否完整 (P <0 .0 1)、肿瘤组织中VEGF的表达水平高度相关 (P <0 .0 0 1)。 结论脑膜瘤对正常脑屏障的破坏是造成瘤周水肿的解剖基础 ,肿瘤细胞分泌的致水肿因子 (VEGF)是造成脑水肿的直接原因。
Objective To find out the related factors leading to edema in meningeal tumor and to explore the mechanism of peritumoral edema. Methods According to the imaging data, the degree of peritumoral edema in 18 patients was semiquantitatively scored. Logistic regression was used to analyze the tumor size, pathological type, completeness of the tumor capsule, whether the drainage vein was compressed, the degree of malignancy of the tumor tissue, Correlation of immunohistochemical staining of growth factor (vascu1arendothelial growth factor, VEGF) and peritumoral edema. Results There was no correlation between peritumoral edema of meningioma and tumor size, with or without venous drainage, pathological type, malignancy degree of tumor tissue, whether the tumor capsule was intact (P <0.01), VEGF expression in tumor tissue The level is highly correlated (P <0. 001). Conclusion The destruction of normal brain barrier by meningiomas is the anatomic basis of peritumoral edema. The induced edema factor (VEGF) secreted by tumor cells is the direct cause of cerebral edema.