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目的 :探讨 HL A- DR4、HL A - DRw5 3抗原与 Vogt-小柳原田综合征的相关性。方法 :用聚合酶链反应一系列引物法对 6 1例 Vogt-小柳原田综合征和 10 2例健康人进行 HL A- DR4、HL A- DRw5 3分型。结果 :患者 HL A - DR4、HL A- DRw5 3阳性率分别为 45 .90 %和 6 2 .2 9% ,正常对照组阳性率则分别为 14.71%和 38.2 4% ,患者与正常对照组之间差异有显著性意义 ( P<0 .0 5 )。结论 :Vogt-小柳原田综合征与 HL A- DR4和 HL A- DRw 5 3有密切的相关性
Objective: To investigate the correlation between HLA-DR4, HLA-DRw5 3 antigen and Vogt-Koyanagi-Harada syndrome. Methods: Sixty-one cases of Vogt-Koyanagi Harada syndrome and 102 healthy controls were genotyped by HL-DR4 and HL-DRw5 3 using polymerase chain reaction (PCR). Results: The positive rates of HL A - DR4 and HL A - DRw5 3 were 45.90% and 62.29% respectively, while those in the normal control group were 14.71% and 38.2% respectively There was a significant difference between the two groups (P <0.05). Conclusions: Vogt-Koyanaga-Harada syndrome is closely related to HL-DR4 and HL-DRw53