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目的:观察左炔诺孕酮宫内缓释系统(曼月乐)对无排卵性子宫出血患者的影响。方法:67例无排卵性子宫出血患者应用曼月乐,记录治疗前后患者月经量、子宫内膜厚度、血红蛋白、子宫内膜的内皮素(ET)含量和并发症变化情况。结果:治疗12个月后,患者月经量和子宫内膜厚度明显下降,血红蛋白明显升高(P<0.01)。子宫异常出血比例明显下降,子宫内膜ET含量明显降低(P<0.05),且随着治疗时间的延长子宫内膜的ET含量降低更明显。并发症率由治疗前的50.74%降低到7.46%。结论:应用曼月乐治疗无排卵性子宫出血患者效果显著。
Objective: To observe the effect of levonorgestrel intrauterine system (Mirena) on patients with anovulatory uterine bleeding. Methods: Sixty-six patients with anovulatory uterine bleeding were treated with Mirena, and the changes of menstrual flow, endometrial thickness, hemoglobin, endothelin (ET) content and complications of the patients before and after treatment were recorded. Results: After 12 months of treatment, the amount of menstrual flow and endometrial thickness were significantly decreased, hemoglobin was significantly increased (P <0.01). The proportion of abnormal uterine bleeding decreased significantly, endometrial ET content was significantly lower (P <0.05), and with the extension of treatment endometrial ET content decreased more significantly. The complication rate decreased from 50.74% before treatment to 7.46%. Conclusion: The application of Mirena music in treating patients with anovulatory uterine bleeding is significant.