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药房自制的注射液经高压消毒和滴眼液贮存较久后,往往引起橡胶塞脱落胶性微粒,影响药液的澄明度。为了提高注射液、滴眼液的澄明度,对橡胶塞几种不同处理方法作了比较,经二年多实践,证明下列二方法较好,现介绍如下。 (一)丙酮、醋酸处理法:将橡胶塞用水搓洗2～3次,除去表面灰尘等异物,干后用丙酮在室温浸泡4～6小时,时加搅动或搓揉,取出用蒸溜水搓洗5～7次,将丙酮回收,然后以0.3%(重/容)醋酸于室温浸泡2～3小时(冬天浸泡时间可延长3小时或稍长,视橡胶制品的质量而定),倾去醋酸水溶液后,用滤过的蒸溜水搓洗5～7次,最后用滤过的蒸溜水煮沸1小时,备用。用此法处理后的橡胶塞表面清净,胶性微粒少。缺点是丙酮价较昂贵,不能大量普遍应用。另外还需注意,醋酸浓度不宜超过0.5%,不能加热温浸,浸泡时间也不能过长,
Pharmacy homemade injection by high pressure disinfection and eye drops stored for a long time, often cause rubber plug off the adhesive particles, affecting the clarity of the liquid. In order to improve the clarity of injection, eye drops, rubber plugs several different treatment methods were compared, after more than two years of practice, the following two methods prove better, are presented below. (A) Acetone, acetic acid method: scrub rubber stopper with water 2 to 3 times, remove the surface dust and other foreign matter, dry with acetone at room temperature for 4 to 6 hours, add agitation or rubbing, remove the scrub with distilled water 5 ~ 7 times, the acetone recovery, and then 0.3% (weight / volume) of acetic acid at room temperature for 2 to 3 hours (winter soaking time can be extended for 3 hours or longer, depending on the quality of rubber products), decanting acetic acid aqueous solution After scrubbing with distilled distilled water 5 to 7 times, and finally with filtered boiled water for 1 hour, spare. Rubber surface treated with this method after cleaning the surface, less plastic particles. The disadvantage is that acetone is more expensive and can not be universally applied. Also note that the concentration of acetic acid should not exceed 0.5%, can not be heated soaking, immersion time can not be too long,