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钙拮抗剂(Calcium Antagonists)又称钙通道阻滞剂,能抑制跨膜钙内流和(或)细胞内的钙释放,降低细胞内游离钙浓度及其利用率,抑制ATP酶的活性,降低心肌收缩力,使肌细胞松弛,血管扩张,降低外周血管阻力,从而使血压降低。临床上钙拮抗剂用于治疗心绞痛,高血压、心律失常、充血性心肌病及缺血性心脏病等。此外,可用于原发性肺动脉高压、缺血性脑卒中,肥厚性心肌病等。钙拮抗剂同时也是开拓分子药理学、生理学研究前沿的实验工具,如研究钙通道结构、生理功能、受体性质和作用机理等。根据化学结构的不同,钙拮抗剂可分为
Calcium Antagonists (Calcium Antagonists), also known as calcium channel blockers, can inhibit transmembrane calcium influx and / or intracellular calcium release, reduce the intracellular free calcium concentration and its utilization, inhibit ATPase activity, reduce Myocardial contractility, so that muscle cell relaxation, vasodilation, reduce peripheral vascular resistance, so that blood pressure. Clinical calcium antagonists for the treatment of angina pectoris, hypertension, arrhythmia, congestive cardiomyopathy and ischemic heart disease. In addition, can be used for primary pulmonary hypertension, ischemic stroke, hypertrophic cardiomyopathy and so on. Calcium antagonists are also experimental tools for pioneering molecular pharmacology and physiology research, such as studying calcium channel structure, physiological functions, receptor properties and mechanism of action. According to the different chemical structure, calcium antagonists can be divided into