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环孢素和一些新研制的免疫抑制剂应用于移植和自身免疫病的治疗，它们主要的副作用是剂量相关的肾毒性。近年来，虽然已明确了这些化合物基本的免疫抑制作用机制，但对其肾毒性的发生和远期效应了解甚少。 两种环抱素类药物 ＳＤＺＩＭＭ １２５、环抱素 Ｇ与环抱素Ａ（ｃｙ－
Cyclosporine and some newly developed immunosuppressive agents are used in the treatment of transplantations and autoimmune diseases and their main side effect is dose-related nephrotoxicity. In recent years, although the basic mechanism of immunosuppression of these compounds has been clarified, little is known about the occurrence and long-term effects of nephrotoxicity. Two Cyclosporin SDZIMM 125, Cyclosporin G and Cy-