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目的探讨p53基因在子宫内膜癌发生发展中的作用,以及p53蛋白表达与其预后相关性。方法应用免疫组织化学方法和TUNEL技术,对子宫内膜腺癌癌变过程中各种病变组织中p53蛋白和细胞凋亡进行测定。结果p53蛋白在正常增生期子宫内膜、早期子宫内膜癌和晚期子宫内膜癌的表达率分别为8.31%、38.9%和57.1%。p53蛋白在晚期子宫内膜癌的表达率明显增高。结论子宫内膜癌的发生发展,受p53基因调控,p53蛋白可能成为评判预后的指标。
Objective To investigate the role of p53 gene in the development of endometrial carcinoma and the relationship between p53 protein expression and prognosis. Methods Immunohistochemistry and TUNEL technique were used to detect p53 protein and apoptosis in various pathological changes of endometrial adenocarcinoma during carcinogenesis. Results The expression rates of p53 protein in normal proliferative endometrium, early endometrial carcinoma and advanced endometrial carcinoma were 8.31%, 38.9% and 57.1%, respectively. The expression of p53 protein in advanced endometrial carcinoma was significantly higher. Conclusions The occurrence and development of endometrial carcinoma is regulated by p53 gene and p53 protein may be an indicator of prognosis.