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以D－半乳糖和人血清白蛋白（HSA）合成无唾液酸糖蛋白受体的特异性配体一半乳糖基拟糖白蛋白（neoglycoalbumin，NGA）；以NGA为载体通过丁二酰基桥将米托蒽醌（mitoxantrone，DHAQ）与其偶联，得到肝靶向药物NGA－DHAQ，紫外光谱和HPLC分析表明：NGA－DHAQ为化学偶联物，在血液中稳定。
Synthesis of asialoglycoprotein receptor-specific ligand, galactosylcalbumin (NGA), with D-galactose and human serum albumin (HSA); Coupled with mitoxantrone (DHAQ), the targeted drug NGA-DHAQ was obtained. UV-Vis spectroscopy and HPLC analysis showed that NGA-DHAQ was chemically conjugated and stable in the blood.