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人淋巴因子活化杀伤(LAK)细胞由白细胞介素-2(IL-2)作用于淋巴细胞后产生,它对肿瘤细胞具有较强的杀伤作用,对人自体肺泡巨噬细胞(AM)是否有裂解作用尚不清楚,为此作者用IL-2体外刺激人外周血单核白细胞(MNC),以4小时~(51)Cr 释放试验分析,结果表明,LAK 细胞对人AM有明显的细胞毒作用,其特点为:①培养4天的AM比新鲜获得的AM 更易被细胞裂解,而且与IL-2浓度之间存在正性剂量依赖性;②经IL-2作用,新鲜
Human lymphokine activated killer (LAK) cells are produced by the action of interleukin-2 (IL-2) on lymphocytes. They have a strong killing effect on tumor cells and have no effect on human autologous alveolar macrophages Cleavage is unclear. To this end, the authors in vitro stimulated human peripheral blood mononuclear cells (MNCs) with IL-2 and analyzed the release profile of 4 hours ~ (51) Cr. The results showed that LAK cells had obvious cytotoxicity on human AM Which is characterized by: ① AM cultured for 4 days is more easily lysed than freshly obtained AM and has a positive dose-dependent relationship with IL-2 concentration; ② IL-2 effect, fresh