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目的:了解金华市人群麻疹抗体水平,及时掌握麻疹流行的新特点、趋势和发病危险因素,为今后制定麻疹防控策略提供科学依据。方法:根据金华市8个县(市、区)近几年的平均发病率,按高、中、低三层,分别选取210名外来流动人口;180名18岁～25岁之间的育龄期妇女;180名孕妇;90名8月龄以下儿童母亲。以其为调查对象,采集血清标本,用ELISA试剂定量检测麻疹IgG抗体。结果:外来流动人口的麻疹抗体阳性率、保护率和抗体几何平均浓度(GMC)分别为66.7%、41.0%、269.9 mIU/ml,各年龄段抗体水平均有显著的统计学差异(P<0.001);育龄期妇女的抗体阳性率、保护率和GMC分别为93.3%、62.8%、1194.1mIU/ml,各地抗体水平除磐安县的保护率和GMC有统计学差异(P<0.05)外,其他无统计学差异(P>0.05);孕妇的抗体阳性率、保护率和GMC分别为94.4%、65.6%、1298.8 mIU/ml,各地抗体水平无统计学差异(P>0.05);小月龄儿童母亲抗体阳性率、保护率和GMC分别为95.6%、81.1%、2503.1 mIU/ml,抗体阳性率和保护率无统计学差异(P>0.05),但未患麻疹儿童母亲的GMC高于患麻疹儿童母亲(t=2.749,P<0.05)。结论:金华市外来流动人口的麻疹抗体水平不高,无法形成有效的免疫屏障,易引起麻疹的暴发或流行;育龄期妇女、孕妇和麻疹患儿母亲的麻疹抗体GMC水平偏低,对<8月龄婴儿无法形成有效的保护,易导致新生儿发病。
OBJECTIVE: To understand the level of measles antibody in Jinhua population, to grasp the new characteristics, trends and risk factors of measles epidemics timely so as to provide a scientific basis for formulating measles prevention and control strategies in the future. Methods: Based on the average morbidity rates of 8 counties (cities and districts) in Jinhua City in recent years, 210 migrant population were selected according to the three levels of high, middle and low levels; 180 age groups of 18 to 25 years of age Women; 180 pregnant women; 90 mothers of children under 8 months of age. Serum samples were collected for the investigation, and measles IgG antibody was detected by ELISA. Results: The measles antibody positive rate, protective rate and geometric mean antibody concentration (GMC) were 66.7%, 41.0% and 269.9 mIU / ml respectively in migrant population. The antibody levels in all age groups were significantly different (P <0.001 ). The antibody positive rate, protective rate and GMC in women of childbearing age were 93.3%, 62.8% and 1194.1mIU / ml, respectively. Except for the protection rate and GMC in Pan’an County, the antibody positive rates were significantly different (P <0.05) The antibody positive rate, protective rate and GMC of pregnant women were 94.4%, 65.6% and 1298.8 mIU / ml, respectively. There was no significant difference in antibody level between the two groups (P> 0.05) The masculine antibody positive rate, protective rate and GMC were 95.6%, 81.1% and 2503.1 mIU / ml, respectively. There was no significant difference in antibody positive rate and protection rate (P> 0.05) Child mother (t = 2.749, P <0.05). Conclusion: The level of measles antibody in floating population of Jinhua City is not high enough to form an effective immune barrier, which may lead to the outbreak or epidemic of measles. The GMC level of measles antibody in pregnant women, pregnant women and measles children is low, Month-old baby can not form an effective protection, easily lead to the onset of newborns.