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由健康大鼠分离得到的肺泡Ⅱ型细胞悬液中加入石英，以50mg／L、100mg／L、200mg／L为石英终浓度培养4h，随石英剂量增加，细胞存活率下降，培养液中乳酸脱氨酶活性增加，光镜和电镜观察均发现细胞的损伤和崩解，提示：石英可直接损伤肺泡Ⅱ型细胞。以25mg／L、50mg／L、100mg／L为石英终浓度培养24h后，培养体系中总磷脂含量升高，培养液中PGE2增加，提示：石英可影响Ⅱ型细胞的分泌功能。石英对肺泡Ⅱ型细胞的上述影响进一步提示，石英对矽肺早期肺泡结构的破坏和肺组织的非特异性炎症具有促进作用，在矽肺病变形成中具有重要意义。
Quartz was obtained from the suspension of alveolar type II cells isolated from healthy rats and incubated at a final concentration of 50 mg / L, 100 mg / L and 200 mg / L for 4 h. With the increase of the quartz dose, the cell viability decreased and the lactate Deaminase activity increased, the damage and disintegration of cells were found by light and electron microscopy, suggesting that quartz could directly damage alveolar type Ⅱ cells. With 25 mg / L, 50 mg / L and 100 mg / L as the final concentration of quartz, the total phospholipid content in the culture system increased and PGE2 increased in the culture medium, suggesting that quartz could affect the secretory function of type II cells. Quartz on alveolar type Ⅱ cells further suggests that the impact of quartz on the early destruction of the alveolar structure of silicosis and lung tissue non-specific inflammation has a role in promoting the formation of silicosis is of great significance.