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胰岛素样生长因子 IGF-Ⅰ与 IGF-Ⅱ在结构与功能上与胰岛素相似,为促丝裂多肽。在体外,它们均有胰岛素样功能;体内,IGF-Ⅰ能以自分泌或旁分泌方式介导生长激素对软骨及其他组织的促生长作用,而 IGF-Ⅱ体内作用尚不清楚。仅知其以旁分泌方式对胎儿或新生儿有作用,其在脑部高度表达表明其对中枢神经系统亦有重要功能。IGF-Ⅰ与IGF-Ⅱ的生理功能均通过细胞表面 IGF-Ⅰ与 IGF-
Insulin-like growth factor IGF-Ⅰ and IGF-Ⅱ in insulin structure and function similar to mitogenic peptide. In vitro, they both have insulin-like functions; in vivo, IGF-I mediates growth-promoting effects of growth hormone on cartilage and other tissues in an autocrine or paracrine manner, and the role of IGF-II in vivo remains unclear. It is only known that it exerts a paracrine effect on the fetus or newborn and that its high expression in the brain indicates that it also has an important function on the central nervous system. The physiological functions of IGF-I and IGF-II are detected by cell surface IGF-I and IGF-