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目的:对几十例交叉配血不合进行原因分析,并提出一些处理方法及解决方案,以指导临床安全用血。方法:检索2011~2014年国内公开发行的主要医学期刊上,有关交叉配血不合的案例报告。总结引起交叉配血不合的各种原因及相应的表现和处理方法。结果:共收集39例交叉配血不合案例报告,其中由红细胞除ABO以外的其他血型系统引起的交叉配血不合24例,由自身抗体引起的交叉配血不合9例,由血清蛋白紊乱及白蛋白球蛋白比例倒置引起的假凝集4例、由药物引起的交叉配血不合2例,主要表现为交叉配血主侧不凝集次侧凝集。结论:提倡自身输血和成分输血,尽量减少或避免输血是减少输血不合及输血反应的主要手段。
OBJECTIVE: To analyze the causes of dozens of cross-incompatible blood tests and to propose some treatment methods and solutions to guide the clinical use of blood. Methods: To retrieve the case reports on the cross-matching of blood in major medical journals published from 2011 to 2014 in China. Summarize the causes of cross-incompatibility with blood and the corresponding performance and treatment. Results: A total of 39 cases of cross-misclassification were collected. Among them, 24 cases were caused by cross-mismatched blood caused by erythrocytes other than ABO, nine cases were caused by autoantibodies, Four cases of false agglutination caused by the inversion of the proportion of globulin were cross-matched by drugs. Two cases showed cross-mismatched blood coagulation. CONCLUSIONS: Advocating self-blood transfusion and component blood transfusion to minimize or avoid blood transfusion is the primary means of reducing transfusion incompatibility and transfusion reactions.