论文部分内容阅读
目的:探讨肥城市食管癌高发的危险因素。方法:采用病例对照研究方法,问卷调查获取资料,分层分析和Logistic回归分析计算统计指标OR。结果:185例患者和204例对照,在调整的因素为年龄、性别、文化水平、吸烟指数、饮酒指数和喝茶指数等因素后,发现食管癌家族史、患有食管病史、吃咸菜多、吃霉变食品、种菜少或不种菜、水源污染为危险因素。对10年前和20年前的饮食组成和营养成分分析发现,居民10年前和20年前的大豆及豆制品摄入量对照组是病例组的2倍。将其按所含的营养成分计算后两组比较,20年前蛋白、铁、磷摄入量多有保护性作用,并呈线形相关。不同因素共同暴露分析显示,食管癌家族史与食管病史、吸烟和饮酒有协同作用,蛋白摄入量增加有拮抗作用。结论:本地区食管癌危险因素的特异性发现为水源污染和蛋白摄入量偏低,大豆蛋白可能有保护作用。
Objective: To investigate the risk factors of high incidence of esophageal cancer in Feicheng City. Methods: The case-control study, questionnaire survey data, stratified analysis and Logistic regression analysis were used to calculate the statistical indicators OR. Results: Among 185 patients and 204 controls, the family history of esophageal cancer, history of esophageal cancer, eating pickles and more were found after adjusting for factors such as age, gender, education level, smoking index, alcohol drinking index and tea drinking index. Moldy food, vegetables less or no vegetables, water pollution as a risk factor. Analysis of the diet composition and nutritional composition 10 years ago and 20 years ago found that the residents’ intake of soybeans and soy products two and ten years ago was twice that of the control group. The nutritional composition of the two groups after the comparison, 20 years ago, protein, iron and phosphorus intake more protective effect, and was linear. Co-exposure analysis of different factors showed that the family history of esophageal cancer and esophageal history, smoking and drinking have synergistic effects, increased protein intake has antagonistic effect. CONCLUSIONS: The specific risk factors of esophageal cancer in this area are found to be low levels of water pollution and protein intake, and soy protein may have a protective effect.