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目的探讨染色体核型分析对男性不育诊断的意义。方法收集染色体核型分析合并精液分析1321例,将其分为无精子症组、重度少弱精子症组、少弱精子症组和精液正常组,综合分析染色体核型异常的比例及分布特点。结果无精子症组和重度少精子症组染色体畸变率分别为26.92%和11.21%,明显高于精液正常组。少弱精子症组染色体畸变率为8.12%,与精液正常组4.89%比较也有明显差异。结论生精功能障碍越严重,染色体异常核型检出率越高。对生精功能障碍及精液正常但原因不明的男性不育患者,染色体核型分析应为其必要检查。
Objective To investigate the significance of chromosome karyotype analysis in the diagnosis of male infertility. Methods 1321 karyotype analysis and semen analysis were collected and divided into azoospermia group, severe oligozoospermia group, oligozoospermia group and normal semen group. The proportion and distribution of chromosomal abnormalities were analyzed. Results The chromosomal aberrations in azoospermia group and severe oligospermia group were 26.92% and 11.21%, respectively, which were significantly higher than those in normal semen group. Chromosome aberration in oligozoospermia group was 8.12%, which was significantly different from 4.89% in normal group. Conclusion The more serious dysfunction of spermatogenesis, the higher the detection rate of chromosomal abnormal karyotype. For spermatogenic dysfunction and sperm normal but unexplained male infertility patients, chromosome karyotype analysis should be its necessary examination.