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1962年美国Lesher等研究发现并第一个用于临床的喹诺酮类药物萘啶酸(NA)至今,30余年来,其系列产品日渐增多,是一类较好的广谱抗菌药物。它已不仅仅囿于抗菌,还扩展到抗人体免疫缺陷病毒和肿瘤方面,本类药物的发展已超过了其它的抗生素,成为和青霉素类、头孢类三足鼎立抗菌之势。由于其对细菌DNA回旋酶具有较强的抑制作用及对细胞壁高度的渗透作用,使细胞失活,因而具有极强的抗菌活性。加
In 1962, the United States Lesher and other studies found that the first clinical quinolone drug nalidixic acid (NA) so far, more than 30 years, increasing its series of products, is a kind of good broad-spectrum antimicrobial drugs. It has not only been antimicrobial, but also extended to anti-human immunodeficiency virus and cancer, the development of this class of drugs has exceeded other antibiotics, and penicillins, cephalosporins tripartite antagonistic potential. Because of its bacterial DNA gyrase has a strong inhibitory effect on the cell wall and a high degree of penetration, so that cells inactivation, which has strong antibacterial activity. plus