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目的观察纳络酮治疗急性脑梗死的临床疗效。方法将60例急性脑梗死患者随机分为治疗组和对照组。治疗组30例在常规治疗基础上加用纳络酮注射液,对照组30例采用单纯常规治疗。检测各组治疗前后β-内啡肽含量,观察临床疗效和神经功能的改变。结果治疗组在治疗后β-内啡肽水平明显低于治疗前。在临床症状和神经功能缺损改善方面,治疗组均优于对照组。结论纳络酮通过降低β-内啡肽水平,阻止急性脑梗死继发性神经元损伤,有效改善临床症状,降低致残率,无明显不良反应,使用安全。
Objective To observe the clinical efficacy of naloxone in the treatment of acute cerebral infarction. Methods Sixty patients with acute cerebral infarction were randomly divided into treatment group and control group. 30 cases in the treatment group were treated with naloxone injection on the basis of routine treatment, and 30 cases in the control group were treated by simple routine. The content of β-endorphin in each group was detected before and after treatment, and the clinical efficacy and neurological function were observed. Results After treatment, the level of β-endorphin in the treatment group was significantly lower than that before treatment. In the clinical symptoms and improvement of neurological deficit, the treatment group were better than the control group. Conclusion Naloxone can prevent the secondary neuronal injury in acute cerebral infarction by decreasing the level of β-endorphin, effectively improve the clinical symptoms, reduce the morbidity, and have no obvious adverse reactions and are safe to use.