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本文通过对47例原发性肝癌(PHC)、40例良性肝病和6例转移性肝癌及正常对照30例同时检测血清甲胎蛋白(AFP)异质体,唾液酸(SA)和5′-NPD(5′-核苷酸磷酸二酯酶同功酶),并与血清AFP 值对照.结果,在PHC 中,AFP 异质体为43.3±22.4%,SA 为2.96±0.7nvnol/L,5′-NPD-V 和Ⅵ带的相对面积分别为2.37±2.82%和2.73±3.2%;而在良性肝病中分别为10.35±17.05%,1.92±0.57nvnol/L,0.40±0.71%和0.36±0.48%(P<0.01).AFP 异质体、SA 和5′-NPD 对PHC 诊断的敏感性分别为82.98%、78.72%和87.23%,特异性分别为90%、82.5%和75%;对AFP 阴性的PHC 诊断阳性率分别为78.26%、73.91%和86.96%.如这4项指标联合检测,可使PHC 诊断阳性率达93.6%,特异性提高到90%.
In this paper, serum alpha-fetoprotein (AFP) heteroplasms, sialic acid (SA) and 5′- were detected simultaneously in 47 patients with primary liver cancer (PHC), 40 patients with benign liver disease, 6 patients with metastatic liver cancer, and 30 normal controls. NPD (5’-nucleotide phosphodiesterase isoenzyme), and compared with serum AFP values. As a result, AFP heterogeneity was 43.3±22.4% in PHC, and SA was 2.96±0.7 nvnol/L,5 The relative areas of the ’-NPD-V and VI bands were 2.37±2.82% and 2.73±3.2%, respectively; while in benign liver disease they were 10.35±17.05%, 1.92±0.57 nvnol/L, 0.40±0.71% and 0.36±0.48, respectively. % (P<0.01). The sensitivities of AFP heteroplasms, SA, and 5′-NPD to the diagnosis of PHC were 82.98%, 78.72%, and 87.23%, respectively, and the specificities were 90%, 82.5%, and 75%, respectively; The positive rate of negative PHC diagnosis was 78.26%, 73.91%, and 86.96%, respectively. If these four indicators were jointly tested, the positive rate of PHC diagnosis was 93.6%, and the specificity was increased to 90%.