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目的 :通过动物实验验证消炎利胆胶囊的利胆抗炎作用。方法 :按生药 3、6、12 g/kg消炎利胆胶囊口服给药 ,观察大鼠胆汁分泌量以及二甲苯致小鼠耳肿胀 ,醋酸对小鼠血管通透性 ,蛋清致大鼠足肿胀和棉球法引起大鼠肉芽组织增生。结果 :消炎利胆胶囊明显增加胆汁分泌量 ,且随剂量增加而增多 ,维持时间达 4h之久 ;抑制二甲苯致小鼠耳肿胀 ;对抗醋酸引起的血管通透性增加 ;对抗蛋清致大鼠足肿胀和棉球所致大鼠肉芽组织增生 ,与对照组比较有显著性差异。结论 :消炎利胆胶囊有明显地利胆抗炎作用。
Objective: To verify the anti-inflammatory and anti-inflammatory effects of Xiaoyan Lidan Capsules through animal experiments. METHODS: Oral administration of 3,6,12 g/kg Xiaoyan Lidan Capsules was used to observe the secretion of bile in rats and swelling of mouse ears induced by xylene. The vascular permeability of mice induced by acetic acid and paw swelling of rats caused by egg white were investigated. And cotton ball method caused rat granulation tissue hyperplasia. RESULTS: Xiaoyan Lidan Capsules significantly increased the amount of bile secretion, increased with dose, and maintained for 4 hours; inhibited xylene-induced ear swelling; increased vascular permeability against acetic acid; Foot swelling and cotton ball-induced granulation tissue proliferation were significantly different from the control group. Conclusion : Xiaoyan Lidan Capsule has obvious anticholinergic effects.