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30年来发现广谱抗生素(氯霉素、四环素和新霉素等)在治疗菌痢时存在很多不良反应。实验证明,一定浓度的四环素抑制氧化磷酸化作用,降低脂酶、氧化还原酶及机体其它酸系统的活性。根据近代概念,环核苷酸(cAMP和cG-MP)的重要作用和细胞生物调节器一样,参加组织增生和免疫反应诱导的调节,它们在许多药物作用机制中也起着作用。完全有理由推测,抗生素对环核苷酸动力学的不良作用是其免疫抑制和毒性作用的基础。有人证实,四环素抑制cAMP的磷酸二酯酶,促使
Over the past 30 years, broad-spectrum antibiotics (chloramphenicol, tetracycline and neomycin, etc.) have been found to have many side effects in the treatment of dysentery. Experiments show that a certain concentration of tetracycline inhibition of oxidative phosphorylation, reducing lipase, oxidoreductase and the body’s other acid system activity. According to modern concepts, the important role of cyclic nucleotides (cAMP and cG-MP), like cell-cell regulators, in the regulation of hyperplasia and immune response induction, also plays a role in many mechanisms of drug action. There is good reason to speculate that the adverse effect of antibiotics on cyclic nucleotide kinetics is the basis for their immunosuppressive and toxic effects. It was confirmed that tetracycline inhibits phosphodiesterase cAMP, prompted