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应用循环伏安法（ＣＶ）和示差脉冲吸附阴极溶出伏安法（ＤＰＡｄＣＳＶ），研究头孢唑啉钠在悬铜汞齐微电极（ＨＣＡＤＭＥ）上的电化学行为及电极反应机理，发现头孢唑啉钠与Ｃｕ（Ⅱ）形成配比为１∶１的配合物，并吸附在ＨＣＡＤＭＥ上，反应电子数为２。并建立了示差脉冲吸附阴极溶出伏安法（ＤＰＡｄＣＳＶ）测定痕量头孢唑啉钠的灵敏方法。其测定的线性范围为６×１０￣（－１）～１×１０￣（－９）ｍｏｌ／Ｌ；检测限约为４×１０￣（－１０）ｍｏｌ／Ｌ（ｔ＿（ａｃ）＝１２０ｓ）。本法用于注射剂中该物质的测定，结果满意。用本法直接测定尿中头孢唑啉钠是可能的。
Cyclic voltammetry (CV) and differential scanning calorimetry cathodic stripping voltammetry (DPAdCSV) were used to study the electrochemical behavior of cefazolin sodium on the copper-cadmium amalgam microelectrode (HCADME) and the electrode reaction mechanism. It was found that cefazolin The complex of sodium and Cu (Ⅱ) is 1: 1 and adsorbed on HCADME. The number of reaction electrons is 2. A sensitive method for the determination of trace cefazolin sodium by differential pulse anodic stripping voltammetry (DPAdCSV) was established. The linear range was 6 × 10 ~ (-1) ~ 1 × 10 ~ (-9) mol / L and the detection limit was 4 × 10 ~ (-10) mol / L (t ac = 120s) . This method is used in the determination of the substance in injection and the result is satisfactory. Direct determination of sodium cefazolin sodium in urine by this method is possible.